1. Why Lyophilized (Freeze-Dried) Powder? In biochemical research, Tirzepatide is a synthetic peptide containing 39 amino acids. Based on peptide stability literature, peptides in aqueous solutions are highly prone to hydrolysis and chemical degradation over time. Lyophilization removes water via sublimation under a vacuum, locking the peptide structure in a stable, amorphous solid state. This process ensures long-term purity and prevents degradation during storage and transit.    

2. Mechanism of Action Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist. Chemically, it is engineered based on the native GIP sequence, conjugated with a C20 fatty diacid moiety to prolong its half-life to approximately 5 days. By simultaneously activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, it synergistically regulates insulin secretion, delays gastric emptying, and significantly suppresses appetite center signaling in the hypothalamus.    

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